Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/47490
Título: | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
Autor(es): | Lopes, Hélder Rocha, Isabel |
Palavras-chave: | yeast genome-scale metabolic model metabolism constraint-based modelling metabolic engineering cell factory constraint-based modeling |
Data: | Ago-2017 |
Editora: | Oxford University Press |
Revista: | FEMS Yeast Research |
Citação: | Lopes, Hélder; Rocha, Isabel, Genome-scale modeling of yeast: chronology, applications and critical perspectives. FEMS Yeast Research, 17(5), fox050, 2017 |
Resumo(s): | Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective on the overall genome-scale modeling procedure, underlining incomplete model validation and evaluation approaches and the quest for the integration of regulatory and kinetic information into yeast GSMMs. A summary of experimentally validated model-based metabolic engineering applications of yeast species is further emphasized, while the main challenges and future perspectives for the field are finally addressed |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/47490 |
ISBN: | 1567-1364 |
DOI: | 10.1093/femsyr/fox050 |
ISSN: | 1567-1356 |
e-ISSN: | 1567-1364 |
Versão da editora: | http://femsyr.oxfordjournals.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46912_1.pdf | 1,81 MB | Adobe PDF | Ver/Abrir |