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https://hdl.handle.net/1822/46389
Título: | Protein-based nanoformulations for α-Tocopherol encapsulation |
Autor(es): | Ghaheh, Fatemeh Shahmoradi Khoddami, Akbar Alihosseini, Farzaneh Gomes, Andreia C Ribeiro, Artur Cavaco-Paulo, Artur Silva, Carla Manuela Pereira Marinho |
Palavras-chave: | α-tocopherol Anti-oxidant activity Protein-based nanoparticles Skin treatment Ultrasounds |
Data: | Mai-2017 |
Editora: | Wiley-Blackwell |
Revista: | Engineering in Life Sciences |
Citação: | Ghaheh, Fatemeh Shahmoradi; Khoddami, Akbar; Alihosseini, Farzaneh; Gomes, Andreia; Ribeiro, Artur; Cavaco-Paulo, Artur; Silva, Carla, Protein-based nanoformulations for α-Tocopherol encapsulation. Engineering in Life Sciences, 17(5), 523-527, 2017 |
Resumo(s): | Nanoparticles of bovine serum albumin (BSA) and silk fibroin (SF) with entrapped α-tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of α-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.+ ability resulting from the synergistic effect between proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/46389 |
DOI: | 10.1002/elsc.201600188 |
ISSN: | 1618-0240 |
e-ISSN: | 1618-2863 |
Versão da editora: | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1618-2863 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CBMA - Artigos/Papers DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46244_1.pdf | 624,29 kB | Adobe PDF | Ver/Abrir |