Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44062
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Leitão, Maria Inês P. S. | por |
dc.contributor.author | Raju, B. Rama | por |
dc.contributor.author | Naik, Sarala | por |
dc.contributor.author | Coutinho, Paulo J. G. | por |
dc.contributor.author | Sousa, Maria João | por |
dc.contributor.author | Gonçalves, M. Sameiro T. | por |
dc.date.accessioned | 2017-01-02T10:03:51Z | - |
dc.date.available | 2017-01-02T10:03:51Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | M. I. P. S. Leitão, B. R. Raju, S. Naik, P. J. G. Coutinho, M. J. Sousa, M. S. T. Gonçalves, “Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents”, Tetrahedron Letters, 2016, 57, 3936-3941. | por |
dc.identifier.issn | 0040-4039 | por |
dc.identifier.uri | https://hdl.handle.net/1822/44062 | - |
dc.description.abstract | A set of four new benzo[a]phenoxazinium chlorides possessing ethyl, propyl, decyl and tetradecyl groups at the 9-amino function of the heterocycle along with a propyl group at the 5-amino position was efficiently synthesised. These compounds displayed fluorescence with maximum emission wavelengths of 673 and 685 nm, in anhydrous ethanol and water. All the benzo[a]phenoxazines were evaluated against the yeast Saccharomyces cerevisiae in a broth microdilution assay. It was found that their antifungal activity depended on the variation in the lengths of the aliphatic chains. The highest MIC activity of 1.56 µM was obtained for compound 7 comprising a di-alkylated propyl substituent at 9-amino position and a propyl chain at the 5-amino position of the heterocycle core. | por |
dc.description.sponsorship | POPH-QREN | por |
dc.description.sponsorship | ERDF | por |
dc.description.sponsorship | FEDER-COMPETE-QREN-EU | por |
dc.description.sponsorship | Thanks are due to the Fundação para a Ciência e Tecnologia (FCT, Portugal) for financial support to the NMR portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho), FCT and FEDER (European Fund for Regional Development)-COMPETE-QREN-EU for financial support to the Research Centres CFUM [PEst-C/FIS/UI0607/2011 (F-COMP-01-0124-FEDER-022711)] and CQ/UM [PEst-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)]. A post-doctoral grant to B. R. Raju (SFRH/BPD/62881/2009) is also acknowledged to FCT, POPH-QREN, FSE. This work was supported by the strategic programme UID/BIA/04050/2013 (POCI-01- 0145-FEDER-007569) funded by national funds through the FCT I.P. and by the ERDF through the COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI). | por |
dc.description.sponsorship | FSE | por |
dc.description.sponsorship | COMPETE2020 | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | PTNMR, Bruker Avance III 400-Univ. Minho | por |
dc.relation | PEst-C/FIS/UI0607/2011 (F-COMP-01-0124-FEDER-022711) | por |
dc.relation | PEst-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716) | por |
dc.relation | SFRH/BPD/62881/2009 | por |
dc.relation | UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) | por |
dc.rights | openAccess | por |
dc.subject | Benzo[a]phenoxazinium chloride | por |
dc.subject | Antimicrobial drugs | por |
dc.subject | Saccharomyces cerevisiae | por |
dc.subject | Nile Blue derivatives | por |
dc.subject | NIR probes | por |
dc.subject | Benzo[a]phenoxazinium chlorides | por |
dc.title | Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S004040391630911X | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 3936 | por |
oaire.citationEndPage | 3941 | por |
oaire.citationIssue | 35 | por |
oaire.citationTitle | Tetrahedron Letters | por |
oaire.citationVolume | 57 | por |
dc.identifier.doi | 10.1016/j.tetlet.2016.07.065 | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Tetrahedron Letters | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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MSTG- Final revised manuscript.pdf | 1,15 MB | Adobe PDF | Ver/Abrir |