Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/33570

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dc.contributor.authorBotelho, F.por
dc.contributor.authorFigueiredo, Luís Pachecopor
dc.contributor.authorLeite, R.por
dc.contributor.authorCarvalho, A.por
dc.contributor.authorTomada, N.por
dc.contributor.authorVendeira, P.por
dc.date.accessioned2015-02-04T14:07:30Z-
dc.date.available2015-02-04T14:07:30Z-
dc.date.issued2012-
dc.identifier.issn0303-4569por
dc.identifier.urihttps://hdl.handle.net/1822/33570-
dc.description.abstractForecast of success with testicular sperm extraction and intracytoplasmic sperm injection (ICSI) remains unknown, as predictive factors have rarely been studied. We evaluated the association among possible predictive factors and a successful biopsy and clinical pregnancy. A consecutive sample of men submitted to a testicular open biopsy in S. João Hospital was used. Patient's age, medical history, testicular volume, spermogram, genetic testing, endocrinologic results, biopsy results and clinical pregnancy information were collected. From the 113 men included, it was possible to retrieve spermatozoa in 79.6% of the cases, which resulted in 58 fertilisations and 22 clinical pregnancies. Retrieving viable spermatozoa on biopsy was associated with the identification of spermatozoa in the spermogram (100.0% versus 74.4%; P = 0.010), diseases causing obstructive infertility (100.0% versus 79.2%; P = 0.036) and no genetic causes detected (82.4% versus 54.5%; P = 0.030). Successful clinical pregnancy was only associated with lower female partner age (31.7 versus 36.0 year; P = 0.001) but not the quality of the spermatozoa or the time until the reproduction cycle. Identification of spermatozoa in the spermogram, diseases causing obstructive infertility and lack of genetic causes for infertility were associated with higher probability of viable spermatozoa retrieval but the female partner age remained the principal determinant of a successful pregnancy.por
dc.language.isoengpor
dc.publisherBlackwell Publishingpor
dc.rightsrestrictedAccesspor
dc.subjectMale infertilitypor
dc.subjectSuccessful pregnancy predictive factorspor
dc.subjectTesticular biopsypor
dc.titlePredictive factors of a successful testicular biopsy and subsequent clinical pregnancypor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1439-0272.2012.01276.x/pdfpor
sdum.publicationstatuspublishedpor
oaire.citationStartPage237por
oaire.citationEndPage242por
oaire.citationIssue4por
oaire.citationTitleAndrologiapor
oaire.citationVolume44por
dc.date.updated2015-01-30T16:41:21Z-
dc.identifier.doi10.1111/j.1439-0272.2012.01276.xpor
dc.identifier.pmid22272771por
dc.subject.wosScience & Technologypor
sdum.journalAndrologiapor
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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