Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32144
Título: | Wavelength-selective cleavage of o-nitrobenzyl and polyheteroaromatic benzyl protecting groups |
Autor(es): | Piloto, Ana M. Costa, Susana P. G. Gonçalves, M. Sameiro T. |
Palavras-chave: | Photolabile protecting groups Selective cleavage o-Nitrobenzyl group Acridine Coumarin |
Data: | Jan-2014 |
Editora: | Elsevier 1 |
Revista: | Tetrahedron |
Resumo(s): | Evaluation of the wavelength-selective cleavage of five photolabile protecting groups from two different families has been performed. Alanine, as a model bifunctional target molecule was masked at the amine terminal with o-nitrobenzyl group and at the carboxylic terminal with benzyl-type nitrogen and oxygen polyheteroaromatics, namely acridine, (thioxo)benzocoumarin and a coumarin built on the julolidine nucleus. The photosensitivity of the corresponding alanine conjugates was studied at selected wavelengths with HPLC/UV and 1H NMR monitoring. The release of the fully deprotected molecule could be achieved by sequential irradiation in variable irradiation times, which were dependent on the heteroaromatic group used. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32144 |
DOI: | 10.1016/j.tet.2013.11.100 |
ISSN: | 0040-4020 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0040402013018334 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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MSTG-Tetrahedron, 2014, 70, 650.pdf Acesso restrito! | 1,02 MB | Adobe PDF | Ver/Abrir |