Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/30540
Título: | The regulation of IL-10 expression |
Autor(es): | Saraiva, Margarida Gabryšová, Leona Howes, Ashleigh O’Garra, Anne |
Data: | 5-Jan-2014 |
Editora: | Springer |
Revista: | Current Topics in Microbiology and Immunology |
Resumo(s): | Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type- or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/30540 |
ISBN: | 9783662434918 |
DOI: | 10.1007/978-3-662-43492-5_8 |
ISSN: | 0070-217X |
Versão da editora: | http://link.springer.com/chapter/10.1007%2F978-3-662-43492-5_8 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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gabrysova l_curr top microb imm 2014 pp.pdf | 761,74 kB | Adobe PDF | Ver/Abrir |