Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29625
Título: | Contribution of limbic norepinephrine to cannabinoid-induced aversion |
Autor(es): | Carvalho, Ana Raquel Franky Gomes Reyes, Arith-Ruth S. Sterling, Robert C. Unterwald, Ellen Bockstaele, Elisabeth J. Van |
Palavras-chave: | Anxiety Conditioned place aversion Nucleus of the solitary tract Saporin Mood disorders |
Data: | 2010 |
Editora: | Springer Verlag |
Revista: | Psychopharmacology |
Resumo(s): | RATIONALE: The cannabinoid system has risen to the forefront in the development of novel treatments for a number of pathophysiological processes. However, significant side effects have been observed in clinical trials raising concerns regarding the potential clinical utility of cannabinoid-based agents. Understanding the neural circuits and neurochemical substrates impacted by cannabinoids will provide a better means of gaging their actions within the central nervous system that may contribute to the expression of unwanted side effects. OBJECTIVES: In the present study, we investigated whether norepinephrine (NE) in the limbic forebrain is a critical determinant of cannabinoid receptor agonist-induced aversion and anxiety in rats. METHODS: An immunotoxin lesion approach was combined with behavioral analysis using a place conditioning paradigm and the elevated zero maze. RESULTS: Our results show that the non-selective CB1/CB2 receptor agonist, WIN 55,212-2, produced a significant place aversion in rats. Further, NE in the nucleus accumbens was critical for WIN 55,212-2-induced aversion but did not affect anxiety-like behaviors. Depletion of NE from the bed nucleus of the stria terminalis was ineffective in altering WIN 55,212-2-induced aversion and anxiety. CONCLUSIONS: These results indicate that limbic, specifically accumbal, NE is required for cannabinoid-induced aversion but is not essential to cannabinoid-induced anxiety. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/29625 |
DOI: | 10.1007/s00213-010-1923-7 |
ISSN: | 0033-3158 1432-2072 |
Versão da editora: | http://link.springer.com/article/10.1007%2Fs00213-010-1923-7 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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carvalho af_ psychopharmacol 2010 posp.pdf | 546,03 kB | Adobe PDF | Ver/Abrir |