Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/23786

Full metadata record
DC FieldValueLanguage
dc.contributor.authorAlmeida, Maria Inês-
dc.contributor.authorReis, R. M.-
dc.contributor.authorCalin, George A.-
dc.date.accessioned2013-04-23T13:25:04Z-
dc.date.available2013-04-23T13:25:04Z-
dc.date.issued2012-09-
dc.identifier.issn1471-2598por
dc.identifier.urihttps://hdl.handle.net/1822/23786-
dc.description.abstractIntroduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5´UTR, coding regions or 3´UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA--RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.por
dc.description.sponsorshipM.I.A. is supported by a PhD fellowship (SFRH/BD/47031/2008) from Fundacão para a Ciência e Tecnologia, Portugal. Dr. Calin is The Alan M. Gewirtz Leukemia & Lymphoma Society Scholar. He is also supported as a Fellow at The University of Texas MD Anderson Research Trust, as a University of Texas System Regents Research Scholar, and by the CLL Global Research Foundation. Work in Dr. Calin’s laboratory is supported in part by an NIH/NCI grant (CA135444), a Department of Defense Breast Cancer Idea Award, Developmental Research Awards in Breast Cancer, Ovarian Cancer, Brain Cancer, Prostate Cancer, Multiple Myeloma, and Leukemia SPOREs, the Laura and John Arnold Foundation, the RGK Foundation and the Estate of C. G. Johnson, Jr. The authors disclose no conflicts of interests and no funding was received in preparation of this manuscript.por
dc.language.isoengpor
dc.publisherInforma Healthcarepor
dc.rightsopenAccesspor
dc.subjectMimicpor
dc.subjectRegulationpor
dc.subjectSpongepor
dc.subjectTherapeutic potentialpor
dc.titleDecoy activity through microRNAs : the therapeutic implicationspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://informahealthcare.com/doi/abs/10.1517/14712598.2012.693470por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1153por
oaire.citationEndPage1159por
oaire.citationIssue9por
oaire.citationTitleExpert Opinion on Biological Therapypor
oaire.citationVolume12por
dc.identifier.doi10.1517/14712598.2012.693470por
dc.identifier.pmid22650365por
dc.subject.wosScience & Technologypor
sdum.journalExpert Opinion on Biological Therapypor
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

Files in This Item:
File Description SizeFormat 
Almeida MI_Expert Opin. Biol. Ther 2012 pp.pdfversão postprint 182,76 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID