Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22103
Título: | A case control study on the diagnostic potential of multiantigen serological tests for tuberculosis |
Autor(es): | Duarte, Raquel Afonso, Andrea Ferreira, Carina Roque, Susana Vasconcelos, Olga Castro, Rui Sarmento Tavares, Margarida Caldas, Cátia Greenwald, Rena Lyashchenko, Konstantin Neves, Margarida Correia Nóbrega, Cláudia |
Palavras-chave: | Tuberculosis Diagnosis Serological tests |
Data: | Mar-2012 |
Editora: | Internet Medical Publishing (IMP) |
Revista: | Archives of Clinical Microbiology |
Resumo(s): | Background: Eradicating tuberculosis (TB) in European countries with high incidence, such as Portugal, rely to a great extent on the ability to perform early accurate diagnosis. For the first time, the diagnostic value of two serologic tests, TB STAT-PAK II and MAPIA, was evaluated for rapid tuberculosis detection in a Portuguese cohort. Materials and Methods: A multicentre case-control study was performed on individuals who had been followed up for TB. Serum was collected from a total of 157 patients divided in: 1) control group with 32 healthy individuals 2) control group with 30 patients with pulmonary diseases other than TB; 3) patients with active TB on anti-TB medication for less than 2 weeks (43 patients), for 1 to 2 months (32 patients) or for more than 6 months (28 patients); 4) 25 patients with active TB co-infected with human immunodeficiency virus (HIV); 5) 29 recently exposed individuals with probable latent TB infection. Sera were tested for the presence of specific mycobacteria antibodies using the TB STAT-PAK II and MAPIA tests and compared with sputum smear microscopy information. Findings: Both of the serological methods showed high specificity. However the two methods had sub-optimal sensitivity, especially in HIV-co-infected patients. Combination of the antibody assays with sputum smear microscopy increased the overall sensitivity of rapid diagnosis. Conclusions: The use of point-of-care serodiagnostic tests may improve early detection of active tuberculosis and contribute for better control programs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22103 |
DOI: | 10.3823/249 |
ISSN: | 1989-8436 |
Versão da editora: | http://imedpub.com/ojs/index.php/acmicrob/article/view/289 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Duarte Raquel_, Arch Clin Microbiol 2012.pdf Acesso restrito! | Documento principal | 1,57 MB | Adobe PDF | Ver/Abrir |