Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/21332
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Barrigón, J. M. | - |
dc.contributor.author | Ramon, R. | - |
dc.contributor.author | Rocha, I. | - |
dc.contributor.author | Valero, F. | - |
dc.contributor.author | Ferreira, Eugénio C. | - |
dc.contributor.author | Montesinos, J. L. | - |
dc.date.accessioned | 2012-12-10T12:15:17Z | - |
dc.date.available | 2012-12-10T12:15:17Z | - |
dc.date.issued | 2012-10-05 | - |
dc.identifier.issn | 1547-5905 | - |
dc.identifier.uri | https://hdl.handle.net/1822/21332 | - |
dc.description.abstract | The productivity of an industrial fermentation process involving a filamentous microbe is heavily dependent on the morphological form adopted by the organism. The development of systems capable of rapidly and accurately characterizing morphology within a given process represents a significant challenge, as the complex phenotypes that are manifested are not easily quantified. Conventional parameters employed in these analyses are often of limited value, as they reveal little about the branching behavior of the organism; an important consideration given the demonstrated link between branching frequency and metabolite production. In this study, the influence of branching behavior on the spatial distribution of mycelia grown in silico is examined through fractal analysis. It is demonstrated that fractal dimension, quantified based on the frequency distribution of parameterized boundary curves, and lacunarity act as robust estimators of branching behavior. The analysis can, in theory, be applied to any morphological form, providing universally applicable process parameters for more complete data acquisition. | por |
dc.description.sponsorship | This work was supported by a grant from the Spanish programme of Chemical Processes Technologies (CTQ2007-60347; CTQ2010-15131), HP2007-0045 from Science and Innovation Ministry, 2009-SGR-00281 and the Reference Network in Biotechnology (XRB) from the DURSI (Generalitat de Catalunya). Support from "Luso-Spanish Integrated Actions" (Action 100/08) are also acknowledged. JMB would like to thank the Spanish Education Ministry for his predoctoral fellowship. | por |
dc.language.iso | eng | por |
dc.publisher | American Institute of Chemical Engineers | por |
dc.rights | openAccess | por |
dc.subject | State estimation | por |
dc.subject | Observers | por |
dc.subject | Recursive least squares | por |
dc.subject | Heterologous protein production | por |
dc.subject | Pichia pastoris | por |
dc.title | State and specific growth estimation in heterologous protein production by Pichia pastoris | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 2966 | por |
oaire.citationEndPage | 2979 | por |
oaire.citationIssue | 10 | por |
oaire.citationTitle | AICHE Journal | por |
oaire.citationVolume | 58 | por |
dc.identifier.doi | 10.1002/aic.12810 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | AICHE Journal | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |