Please use this identifier to cite or link to this item:

TitleIN VIVO and IN VITRO 27AI NMR studies of aluminium(III) chelates of triazacyclononane polycarboxylate ligands
Author(s)André, João P.
Mäcke, Helmut
Kaspar, Armin
Kunnecke, Basil
Zehnder, Margareta
Macko, Ludwig
KeywordsAluminum chelates
27Al NMR
Al-27 NMR
Issue date2002
JournalJournal of Inorganic Biochemistry
Citation"Journal of inorganic biochemistry". 88 (2002) 1-6.
Abstract(s)The metallic radioisotope of a known radiopharmaceutical chelate, 67Ga(NOTA) (NOTA=1,4,7-triazacyclonane-1,4,7-triacetic acid), used for tumor detection, was substituted by the chemically similar but non radioactive aluminum ion. Our aim was to detect and evaluate the in vivo behavior of the chelate. For this purpose, Al(NOTA) and the related chelate Al(NODASA) (NODASA=1,4,7-triazacyclononane-1-succinic acid-4,7-diacetic acid) were studied using in vitro and in vivo 27Al NMR spectroscopy in rats. Both chelates showed high stability towards acid catalyzed dissociation and their 27Al NMR resonances are characteristic of highly symmetrical species, with chemical shifts within the range for octahedral or pseudo-octahedral geometries. The thermodynamic stability constant of the novel chelate Al(NODASA) was estimated using 27Al NMR. The obtained value suggested that the chelate does not undergo in vivo demetalation by transferrin. The in vivo spectroscopic studies and the analysis of blood and urine samples for Al(III) concentrations indicated that the chelates remain intact under physiological conditions and that they are mainly eliminated from the body through the kidneys.
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
mso662DF.pdf73,06 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID