Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/17433
Título: | Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
Autor(es): | Sampaio-Marques, Belém Felgueiras, Carolina Silva, Alexandra Rodrigues, Fernando José dos Santos Ludovico, Paula |
Palavras-chave: | Autophagy Chronological aging Proteotoxic stress Ras/cAMP dependent protein kinase Sch9 Target of rapamycin Ras/cAMP-dependent protein kinase (protein kinase A) target of rapamycin (TOR) |
Data: | Out-2011 |
Editora: | Biochemical Society |
Revista: | Biochemical Society Transactions |
Resumo(s): | Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation of yeast lifespan, also converge on a common targeted process: autophagy. The molecular mechanisms underlying the regulation of autophagy and aging by these signalling pathways in yeast, with special attention to theTOR pathway, are discussed in the present paper. The question of whether or not autophagy could contribute to yeast cell death occurring during CLS (chronological lifespan) is discussed in the light of our findings obtained after autophagy activation promoted by proteotoxic stress. Autophagy progressively increases in cells expressing the aggregation-prone protein α-synuclein and seems to participate in the early cell death and shortening of CLS under these conditions, highlighting that autophagic activity should be maintained below physiological levels to exert its promising anti-aging effects. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/17433 |
DOI: | 10.1042/BST0391466 |
ISSN: | 0300-5127 |
Versão da editora: | http://www.biochemsoctrans.org/bst/039/bst0391466.htm |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Belem SM_Biochem Soc Trans 2011 pp.pdf | Versão post print | 647,38 kB | Adobe PDF | Ver/Abrir |