Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/948

TitleLanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents
Author(s)André, João P.
Geraldes, Carlos F. G. C.
Martins, J. A. R.
Merbach, André E.
Prata, M. I. M.
Santos, A. C.
Lima, J. J. Pedroso de
Tóth, Éva
KeywordsGlycoconjugates
Lanthanides
Lectins
Macrocycles
Magnetic resonance imaging
Issue date2004
PublisherWiley
JournalChemistry - A European Journal
CitationANDRÉ, João P. [et al.] - Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents. “Chemistry : a european journal” [Em linha]. 10:22 (2004) 5804-5816. [Consult. 30 Mar. 2005]. Disponível em: http://www3.interscience.wiley.com/cgi-bin/jissue/109744134
Abstract(s)The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy).
TypeArticle
URIhttp://hdl.handle.net/1822/948
DOI10.1002/chem.200400187
ISSN0947-6539
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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