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TitleDiaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex®
Author(s)Scuglia, Marianna
Frazão, Laura P.
Miranda, Alice Augusta Macedo
Martins, Albino
Barbosa-Sequeira, Joana
Coimbra, Diana
Longatto, Adhemar
Reis, R. L.
Silva, Cristina Isabel Nogueira
Neves, N. M.
Correia-Pinto, Jorge
KeywordsCongenital diaphragmatic hernia repair
Decellularized human chorion membrane
Electrospun fibrous mesh
Thoracoscopic surgery
Issue date2024
PublisherSpringer Nature
JournalPediatric Surgery International
CitationScuglia M., Frazão L. P., Miranda A., Martins A., Barbosa-Sequeira J., Coimbra D., Longatto-Filho A., Reis R. L., Nogueira-Silva C., Neves N. M., Correia-Pinto J. Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex, Pediatric Surgery International, Vol. 4, pp. 7, doi:, 2023
Abstract(s)Background Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 animals each, determined by the type of patch used during thoracoscopic diaphragmatic hernia repair (Gore-Tex®, polycaprolactone electrospun membrane-PCLem, and decellularized human chorion membrane-dHCM). After 7 weeks, all animals were euthanized, followed by necropsy for diaphragmatic evaluation and histological analysis. Results Thoracoscopic defect creation and diaphragmatic repair were performed without any technical difculty in all groups. However, hernia recurrence rate was 0% in Gore-Tex®, 50% in PCLem and 100% in dHCM groups. At euthanasia, Gore-Tex® patches appeared virtually unchanged and covered with a fbrotic capsule, while PCLem and dHCM patches were replaced by either foppy connective tissue or vascularized and foppy regenerated membranous tissue, respectively. Conclusion Gore-Tex® was associated with a higher survival rate and lower recurrence. Nevertheless, the proposed biodegradable membranes were associated with better tissue integration when compared with Gore-Tex®.
DescriptionPublished: 24 November 2023
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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