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TitleBiocomposite macrospheres based on strontium-bioactive glass for application as bone fillers
Author(s)Oliveira, Ivone Regina de
Gonçalves, Isabela dos Santos
Wallace dos Santos, Kennedy
Lança, Maria Carmo
Vieira, Tânia
Silva, Jorge Carvalho
Cengiz, I. F.
Reis, R. L.
Oliveira, Joaquim M.
Borges, João Paulo Miranda Ribeiro
KeywordsBioactive glass
Bone defects
Issue dateAug-2023
PublisherAmerican Chemical Society
JournalACS Materials Au
CitationOliveira I. R., Gonçalves I., Wallace dos Santos K., Lança M. C., Vieira T., Silva J., Cengiz I. F., Reis R. L., Oliveira J. M., Borges J. P. Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers, ACS Materials AU, doi:10.1021/acsmaterialsau.3c00048, 2023
Abstract(s)Traditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which can limit bone ingrowth. The use of novel biocomposite sphere formulations comprising bioactive factors as bone fillers are most advantageous, as it simultaneously allows for packing the particles in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately a superior new bone formation. In this work, we develop and characterize novel biocomposite macrospheres of Sr-bioactive glass using sodium alginate, polylactic acid (PLA), and chitosan (CH) as encapsulating materials for finding applications as bone fillers. The biocomposite macrospheres that were obtained using PLA have a larger size distribution and higher porosity and an interconnectivity of 99.7%. Loose apatite particles were observed on the surface of macrospheres prepared with alginate and CH by means of soaking into a simulated body fluid (SBF) for 7 days. A dense apatite layer was formed on the biocomposite macrospheresâ surface produced with PLA, which served to protect PLA from degradation. In vitro investigations demonstrated that biocomposite macrospheres had minimal cytotoxic effects on a human osteosarcoma cell line (SaOS-2 cells). However, the accelerated degradation of PLA due to the degradation of bioactive glass may account for the observed decrease in SaOS-2 cells viability. Among the biocomposite macrospheres, those composed of PLA exhibited the most promising characteristics for their potential use as fillers in bone tissue repair applications.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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