Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76331
Título: | Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan |
Autor(es): | Correia, Catia Sousa, Rita Alexandra Oliveira Vale, A. Catarina Peixoto, Daniela Silva, Tiago H. Reis, R. L. Pashkuleva, I. Alves, N. M. |
Palavras-chave: | Bioadhesive Catechol Chitosan Collagen Soft tissue repair |
Data: | Fev-2022 |
Editora: | Elsevier |
Revista: | Colloids and Surfaces B: Biointerfaces |
Citação: | Correia C., Sousa R. O., Vale A. C., Peixoto D., Silva T. H., Reis R. L., Pashkuleva I., Alves N. M. Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan, Colloids And Surfaces B-biointerfaces, Vol. 213, pp. 112409, doi:10.1016/j.colsurfb.2022.112409, 2022 |
Resumo(s): | We describe bioadhesive membranes developed from marine renewable biomaterials, namely chitosan and collagen extracted from fish skins. Collagen was functionalized with catechol groups (Coll-Cat) to provide the membranes with superior adhesive properties in a wet environment and blended with chitosan to improve the mechanical properties. The blended membranes were compared to chitosan and chitosan blended with unmodified collagen in terms of surface morphology, wettability, weight loss, water uptake, mechanical and adhesive properties. The metabolic activity, the viability and the morphology of L929 fibroblastic cells seeded on these membranes were also assessed. Our results show that the functionalization with catechol groups improves the adhesive and mechanical properties of the membranes and enhances cell attachment and proliferation. These data suggest that the developed marine origin-raw membranes present a potential towards the restoration of the structural and functional properties of damaged soft tissues. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76331 |
DOI: | 10.1016/j.colsurfb.2022.112409 |
ISSN: | 0927-7765 |
Versão da editora: | https://doi.org/10.1016/j.colsurfb.2022.112409 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20736-correia-et-al.pdf | 6,33 MB | Adobe PDF | Ver/Abrir |