Please use this identifier to cite or link to this item:

TitleGlycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
Author(s)Costa, Rui Filipe Ramos
Reis, R. L.
Pashkuleva, I.
KeywordsChondroitin sulfate
Dermatan sulfate
Electrostatic complexation
Hyaluronic acid
Keratan sulfate
Supramolecular assembly
Issue dateJan-2022
PublisherTaylor & Francis
JournalInternational Materials Reviews
CitationCosta R. R., Reis R. L., Pashkuleva I. Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices, International Materials Reviews, doi:10.1080/09506608.2022.2026860, 2022
Abstract(s)The innate negative charge of glycosaminoglycans (GAG) is in the origin of their bioactivity: it drives their spontaneous complexation with positively charged biomolecules and ions, regulating homeostatic functions by protein stabilization, protection and activation. Copycatting these interactions enables different supramolecular approaches towards the assembly of biofunctional devices. Such approaches allow processing under physiological conditions and thus, they are of unprecedented biocompliance for device build-up compared to conventional methods based on chemical cross-linkers, volatile and organic solvents, and high temperatures. We review different set-ups based on GAG electrostatic complexation and showcase their application towards the development of diverse therapeutic systems. We also discuss challenges associated with GAG complexation into intricate three-dimensional networks holding back the widespread use of these methods. Finally, we anticipate that conscious choice of GAG with distinct polyanionic strength and specific bioactivity will make possible the fabrication of constructs with personalized and customized properties in the nearest future.
DescriptionPublished online: 19 Jan 2022
Publisher version
AccessEmbargoed access (2 Years)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
  Until 2024-02-01
8,18 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID