Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/75603

TitleGlycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
Author(s)Costa, Rui Filipe Ramos
Reis, R. L.
Pashkuleva, I.
KeywordsChondroitin sulfate
Dermatan sulfate
Electrostatic complexation
Heparin
Hyaluronic acid
Keratan sulfate
Polyelectrolytes
Supramolecular assembly
Issue dateJan-2022
PublisherTaylor & Francis
JournalInternational Materials Reviews
CitationCosta R. R., Reis R. L., Pashkuleva I. Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices, International Materials Reviews, doi:10.1080/09506608.2022.2026860, 2022
Abstract(s)The innate negative charge of glycosaminoglycans (GAG) is in the origin of their bioactivity: it drives their spontaneous complexation with positively charged biomolecules and ions, regulating homeostatic functions by protein stabilization, protection and activation. Copycatting these interactions enables different supramolecular approaches towards the assembly of biofunctional devices. Such approaches allow processing under physiological conditions and thus, they are of unprecedented biocompliance for device build-up compared to conventional methods based on chemical cross-linkers, volatile and organic solvents, and high temperatures. We review different set-ups based on GAG electrostatic complexation and showcase their application towards the development of diverse therapeutic systems. We also discuss challenges associated with GAG complexation into intricate three-dimensional networks holding back the widespread use of these methods. Finally, we anticipate that conscious choice of GAG with distinct polyanionic strength and specific bioactivity will make possible the fabrication of constructs with personalized and customized properties in the nearest future.
TypeArticle
DescriptionPublished online: 19 Jan 2022
URIhttps://hdl.handle.net/1822/75603
DOI10.1080/09506608.2022.2026860
ISSN0950-6608
e-ISSN1743-2804
Publisher versionhttps://www.tandfonline.com/doi/full/10.1080/09506608.2022.2026860
Peer-Reviewedyes
AccessEmbargoed access (2 Years)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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