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|Title:||2,4,5-(Hetero)arylimidazole probe for the selective detection of fluoride anion|
|Author(s):||Ramos, Nuna L. P.|
Nogueira, Mariana B.
Costa, Susana P. G.
Raposo, M. Manuela M.
|Citation:||Ramos, N. L. P.; Nogueira, M. B.; Costa, S. P. G.; Raposo, M. M. M. 2,4,5-(Hetero)arylimidazole probe for the selective detection of fluoride anion. P05, 4th Symposium on Medicinal Chemistry of the University of Minho, Braga, Portugal, 24 de maio 2019.|
|Abstract(s):||Selective recognition of anions is a very dynamic topic in supramolecular chemistry which has been widely investigated recently due to the importance of these analytes in a broad variety of medicinal, environmental and biological processes. Fluoride anion is of particular importance due to its established role in dental care and treatment of osteoporosis, and, consequently its straightforward recognition is vital. 2,4,5-Triaryl-imidazoles are versatile compounds with application in medicine, due to their biological activity, and materials and biomedical sciences, for their interesting optical properties which can be tuned by careful selection of substituents at positions 2, 4 and 5. In fact, replacement of the aryl group by a heterocyclic moiety results in larger π-conjugated systems with improved optical properties for several applications in materials and in medicinal chemistry as Two Photon Absorption (TPA) fluorophores for bioimaging, DNA intercalators, optical chemosensors, among others. In this communication, we report the synthesis of a new diphenylimidazole, substituted at position 2 with a carbazolyl group using a simple synthetic methodology and an easy purification procedure. The new compound was characterized by the usual techniques and a detailed photophysical study was undertaken. The evaluation of the imidazole derivative as a fluorimetric chemosensor was carried out in acetonitrile in the presence of relevant anions with biological, medicinal and environmental relevance. The results obtained showed that the new compound exhibited selectivity to the fluoride anion.|
|Access:||Embargoed access (2 Years)|
|Appears in Collections:||CDQuim - Comunicações e Proceedings|
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