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TitleCannabidiol in neurological and neoplastic diseases: Latest developments on the molecular mechanism of action
Author(s)Ozarowski, M.
Karpinski, T. M.
Zielinska, A.
Souto, Eliana
Wielgus, K.
KeywordsAlzheimers disease
Cannabis sativa
Mechanism of action
Multiple sclerosis
Pharmacological activity
Issue date21-Apr-2021
JournalInternational Journal of Molecular Sciences
CitationOżarowski, M., Karpiński, T. M., Zielińska, A., Souto, E. B., & Wielgus, K. (2021). Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. International Journal of Molecular Sciences, 22(9), 4294
Abstract(s)As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimers disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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