Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/67551

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dc.contributor.authorOlsson, I. A. S.por
dc.contributor.authorCosta, A.por
dc.contributor.authorNobrega, Claudiapor
dc.contributor.authorRoque, Susanapor
dc.contributor.authorCorreia-Neves, Mpor
dc.date.accessioned2020-10-16T16:21:23Z-
dc.date.issued2010-04-
dc.identifier.citationOlsson, I. A. S., Costa, A., Nobrega, C., Roque, S., et. al. (2010). Environmental enrichment does not compromise the immune response in mice chronically infected with Mycobacterium avium. Scandinavian journal of immunology, 71(4), 249-257por
dc.identifier.issn0300-9475-
dc.identifier.urihttp://hdl.handle.net/1822/67551-
dc.description.abstractResearch on infectious diseases using animal models has been a successful example of translational research. However, because chronic infections are still one of the main causes of death and disability in the world, it is expected that a great number of mice will continue to be used to address this subject. Although increasing awareness regarding animal welfare has led to novel recommendations for animal housing enrichment, studies evaluating the impact of these modifications on the immune response to infection are lacking. The present study shows that validated and recommended simple environmental enrichment does not interfere with the immune response to chronic infection with Mycobacterium avium for up to 20 weeks, as assessed by the bacterial load in the spleen and lung, by the number and activation status of the main cell populations of the immune system and the serum concentration of interferon-gamma. Therefore, enrichment can be encouraged without concern regarding comparability of results among laboratories studying this type of chronic infections.por
dc.description.sponsorshipECLAM and ESLAV Foundation. CN and SR are recipients of PhD fellowships from Portuguese Foundation for Science and Technology (FCT)por
dc.language.isoengpor
dc.publisherWileypor
dc.rightsrestrictedAccesspor
dc.subjectAnimalspor
dc.subjectCell Separationpor
dc.subjectChronic Diseasepor
dc.subjectFemalepor
dc.subjectFlow Cytometrypor
dc.subjectLymphocyte Activationpor
dc.subjectMicepor
dc.subjectMice, Inbred BALB Cpor
dc.subjectMycobacterium aviumpor
dc.subjectTuberculosispor
dc.subjectHousing, Animalpor
dc.titleEnvironmental enrichment does not compromise the immune response in mice chronically infected with Mycobacterium aviumpor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3083.2010.02371.xpor
oaire.citationStartPage249por
oaire.citationEndPage257por
oaire.citationIssue4por
oaire.citationVolume71por
dc.identifier.essn1365-3083-
dc.identifier.doi10.1111/j.1365-3083.2010.02371.xpor
dc.date.embargo10000-01-01-
dc.identifier.pmid20384868por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalScandinavian Journal of Immunologypor
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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