Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67373
Título: | Decreasing arterial aging by controlling blood pressure levels and hypertension: a step forward |
Autor(es): | Scuteri, Angelo Cunha, Pedro Guimarães |
Palavras-chave: | Age Factors Antihypertensive Agents Blood Pressure Cerebrovascular Circulation Cognition Humans Hypertension Hypotension Risk Assessment Risk Factors Risk Reduction Behavior Treatment Outcome Vascular Stiffness Aging Arterial aging pulse wave velocity hypertension treatment cognitive impairment |
Data: | Nov-2012 |
Editora: | Bentham Science Publishers |
Revista: | Current Vascular Pharmacology |
Resumo(s): | Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67373 |
DOI: | 10.2174/157016112803520954 |
ISSN: | 1570-1611 |
Versão da editora: | https://www.eurekaselect.com/103933/article |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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010AD.pdf Acesso restrito! | 40,67 kB | Adobe PDF | Ver/Abrir |