Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65533
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Agostinis-Sobrinho, César | por |
dc.contributor.author | Rosário, Rafaela | por |
dc.contributor.author | Santos, Rute | por |
dc.contributor.author | Norkiene, Sigute | por |
dc.contributor.author | Mota, Jorge | por |
dc.contributor.author | Rauckienė-Michaelsson, Alona | por |
dc.contributor.author | González-Ruíz, Katherine | por |
dc.contributor.author | Izquierdo, Mikel | por |
dc.contributor.author | Garcia-Hermoso, Antonio | por |
dc.contributor.author | Ramírez-Vélez, Robinson | por |
dc.date.accessioned | 2020-05-29T14:25:43Z | - |
dc.date.available | 2020-05-29T14:25:43Z | - |
dc.date.issued | 2020-05-18 | - |
dc.identifier.citation | Agostinis-Sobrinho, C.; Rosário, R.; Santos, R.; Norkiene, S.; Mota, J.; Rauckienė-Michaelsson, A.; González-Ruíz, K.; Izquierdo, M.; Garcia-Hermoso, A.; Ramírez-Vélez, R. Higher Cardiorespiratory Fitness Levels May Attenuate the Detrimental Association between Weight Status, Metabolic Phenotype and C-Reactive Protein in Adolescents—A Multi-Cohort Study. Nutrients 2020, 12, 1461. | por |
dc.identifier.uri | https://hdl.handle.net/1822/65533 | - |
dc.description.abstract | Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age- and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy non-overweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders. | por |
dc.description.sponsorship | The Research Centre on Physical Activity Health and Leisure (CIAFEL) is supported by UID/DTP/00617/2013 (FCT). R.S. has a Discovery Early Career Research Award from the Australian Research Council (DE150101921). The FUPRECOL Study was carried out with the financial support of Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología “Francisco José de Caldas” COLCIENCIAS (Contract Nº 671-2014 Code 122265743978). The authors are grateful to the Bogota District Education Secretary for the data used in this study. The authors also thank the participating Bogota District students, teachers, schools and staff. This study was funded by the Department of Education (Grand number: CENEDUCA1/2019) of the Government of Navarra (Spain). A.G.-H. is a Miguel Servet Fellow (Instituto de Salud Carlos III—CP18/0150). R.R.-V. is funded in part by a Postdoctoral Fellowship Resolution ID 420/2019 of the Universidad Pública de Navarra. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147454/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Aerobic | por |
dc.subject | Fitness | por |
dc.subject | Healthy | por |
dc.subject | Inflammation | por |
dc.subject | Metabolic | por |
dc.subject | Obese | por |
dc.subject | Youth | por |
dc.title | Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents - a multi-Cohort study | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/12/5/1461 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2020-05-28T14:07:40Z | - |
dc.identifier.eissn | 2072-6643 | - |
dc.identifier.doi | 10.3390/nu12051461 | por |
dc.identifier.pmid | 32443557 | por |
dc.subject.fos | Ciências Médicas::Ciências da Saúde | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nutrients | por |
oaire.version | VoR | por |
Aparece nas coleções: | ESE-CIE - Artigos em Revistas Internacionais / Papers in International Journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nutrients-12-01461-v2.pdf | 877,89 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons