Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/64333
Título: | Antimicrobial resistance three ways: healthcare crisis, major concepts, and the relevance of biofilms |
Autor(es): | Jorge, Paula Magalhães, Andreia Patrícia Alves Grainha, Tânia Raquel Rodrigues Alves, Diana Filipa Barros Sousa, Ana Margarida Lopes, Susana P. Pereira, Maria Olívia |
Palavras-chave: | Antimicrobial Resistance Tolerance Persistence Biofilms Quorum Sensing Polymicrobial Infection |
Data: | Ago-2019 |
Editora: | Oxford University Press |
Revista: | FEMS Microbiology Ecology |
Citação: | Jorge, Paula; Magalhães, Andreia P.; Grainha, Tânia; Alves, Diana; Sousa, Ana Margarida; Lopes, Susana P.; Pereira, Maria Olívia, Antimicrobial resistance three ways: healthcare crisis, major concepts, and the relevance of biofilms. FEMS Microbiology Ecology, 95(8), fiz115, 2019 |
Resumo(s): | Worldwide, infections are resuming their role as highly effective killing diseases, as current treatments are failing to respond to the growing problem that is antimicrobial resistance (AMR). The social and economical burden of AMR seems ever rising, with health- and research-related organizations rushing to collaborate on a worldwide scale to find effective solutions. Resistant bacteria are spreading even in first-world nations, being found not only in healthcare-related settings, but also in food and in the environment. In this mini-review, the impact of AMR in healthcare systems and the major bacteria behind it are highlighted. Ecological aspects of AMR evolution and the complexity of its molecular mechanisms are explained. Major concepts, such as intrinsic, acquired, and adaptive resistance, as well as tolerance and heteroresistance, are also clarified. More importantly, the problematic of biofilms and their role in AMR, namely its main resistance and tolerance mechanisms, is elucidated. Finally, some of the most promising anti-biofilm strategies being investigated are reviewed. Much is still to be done regarding the study of AMR and the discovery of new anti-biofilm strategies. Gladly, considerable research on this topic is generated every day and increasingly concerted actions are being engaged globally to try and tackle this problem. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/64333 |
DOI: | 10.1093/femsec/fiz115 |
ISSN: | 0168-6496 |
Versão da editora: | https://academic.oup.com/femsec |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51854_1.pdf | 2 MB | Adobe PDF | Ver/Abrir |