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TitleEGFR and microvessel density in canine malignant mammary tumours
Author(s)Carvalho, Maria Isabel
Guimarães, Maria João
Pires, Isabel
Prada, Justina
Carvalho, Ricardo Emanuel Silva
Lopes, Carlos
Queiroga, Felisbina L.
Dog Diseases
ErbB Receptors
Gene Expression Regulation, Neoplastic
Mammary Neoplasms, Animal
Neoplasm Metastasis
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1
Canine mammary tumours
Issue dateDec-2013
JournalResearch in Veterinary Science
CitationCarvalho, M. I., Guimarães, M. J., Pires, I., Prada, J., Silva-Carvalho, R., Lopes, C., & Queiroga, F. L. (2013). EGFR and microvessel density in canine malignant mammary tumours. Research in veterinary science, 95(3), 1094-1099.
Abstract(s)The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor which has been shown to have an important role in human breast cancer. Its role appears to be associated with increased angiogenesis and metastasis. In order to clarify its role in canine mammary tumours (CMT), 61 malignant neoplasms were studied by using immunohistochemistry, comparing expression of EGFR, microvessel density (MVD) by CD31 immunolabelling and characteristics of tumour aggressiveness. High EGFR immunoexpression was statistically significantly associated with tumour size, tumour necrosis, mitotic grade, histological grade of malignancy and clinical stage. High CD31 immunoreactivity was statistically significantly associated with tubule formation, histological grade of malignancy and clinical stage. A positive correlation between EGFR and CD31 immunoexpression (r = 0.843; P < 0.001) was also observed. Results suggest that an over-expression of EGFR may contribute to increased angiogenesis and aggression in malignant CMT, presenting the possibility of using EGFR inhibitors in the context of metastatic disease treatment.
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Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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