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https://hdl.handle.net/1822/61463
Título: | The C677T polymorphism in MTHFR is not associated with migraine in Portugal |
Autor(es): | Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, P. |
Palavras-chave: | Adult Case-Control Studies Female Folic Acid Genotype Homozygote Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Migraine with Aura Migraine without Aura Polymorphism, Genetic Portugal Risk Factors association study folate metabolism homocysteine cephalalgia |
Data: | 2008 |
Editora: | Hindawi Publishing Corporation |
Revista: | Disease Markers |
Citação: | Ferro, A., Castro, M. J., Lemos, C., Santos, M., Sousa, A., Pereira-Monteiro, J., ... & Maciel, P. (2008). The C677T polymorphism in MTHFR is not associated with migraine in Portugal. Disease markers, 25(2), 107-113. |
Resumo(s): | Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetetrahydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61463 |
DOI: | 10.1155/2008/178679 |
ISSN: | 0278-0240 |
e-ISSN: | 1875-8630 |
Versão da editora: | https://www.hindawi.com/journals/dm/2008/178679/abs/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Ferro-2008-The-ct-polymorphism-inmthfris-not-a.pdf | 1,17 MB | Adobe PDF | Ver/Abrir |