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TitleFucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo
Author(s)Oliveira, Ana Catarina Freitas Salazar
Granja, Sara Costa
Neves, N. M.
Reis, R. L.
Baltazar, Fátima
Silva, Tiago José Quinteiros Lopes Henriques
Martins, Albino
Issue date2019
JournalCarbohydrate Polymers
CitationOliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., Martins A. Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo, Carbohydrate Polymers, Vol. 223, doi:10.1016/j.carbpol.2019.115034, 2019
Abstract(s)Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em revistas internacionais / Papers in international journals

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