Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/60582

Titleß-carotene and -tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: characterization, dynamic in vitro digestion and cell viability study
Author(s)Gomes, G. V. L.
Sola, M. R.
Rochetti, A. L.
Fukumasu, H.
Vicente, A. A.
Pinho, S. C.
Keywordsphase inversion temperature
solid lipid nanoparticles
Astrocaryum murumuru
beta-carotene
bioaccessibility
Issue date14-Mar-2019
PublisherTaylor & Francis
JournalJournal of Microencapsulation
CitationGomes, G. V. L.; Sola, M. R.; Rochetti, A. L.; Fukumasu, H.; Vicente, António A.; Pinho, S. C., ß-carotene and -tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: characterization, dynamic in vitro digestion and cell viability study. Journal of Microencapsulation, 36(1), 43-52, 2019
Abstract(s)Hydrophobic bioactives can be more easily incorporated into food and have their bioavailability enhanced if nanostructured lipid carriers (NLC) are used as carriers. In the present study, beta-carotene-loaded NLC were produced by low emulsificationusing murumuru butter and a mixture of Span 80 and Cremophor RH40 as surfactants. Their average diameter was 35nm andalpha-tocopherol was required to protect the encapsulated -carotene. Besides the evaluation of their physicochemical stability, NLC were submitted to dynamic in vitrodigestion and cell viability assays with Caco-2 and HEPG cells. The bioaccessibility of beta-carotene in the dynamic system was about 42%.Regarding cell viability, results indicated NLC were toxic to the cell cultures tested. Such high toxicity is probably related to the type of surfactant used and tothe extremely reduced particle size, which may have led to an intense and fast permeation of the NLC through the cells.
TypeArticle
URIhttp://hdl.handle.net/1822/60582
DOI10.1080/02652048.2019.1585982
ISSN0265-2048
e-ISSN1464-5246
Publisher versionhttp://www.tandfonline.com/action/journalInformation?journalCode=imnc20
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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