Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/60303

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dc.contributor.authorVeloso, Sérgio Rafael Silvapor
dc.contributor.authorMagalhães, Carlos A. B.por
dc.contributor.authorRodrigues, Ana Rita Oliveirapor
dc.contributor.authorVilaça, Maria Helena Pereirapor
dc.contributor.authorQueiroz, Maria João R. P.por
dc.contributor.authorMartins, J. A.por
dc.contributor.authorCoutinho, Paulo J. G.por
dc.contributor.authorFerreira, Paula M. T.por
dc.contributor.authorCastanheira, Elisabete M. S.por
dc.date.accessioned2019-05-13T16:01:42Z-
dc.date.issued2019-04-23-
dc.identifier.citationPhysical Chemistry Chemical Physics, 2019, DOI: 10.1039/C9CP00352Epor
dc.identifier.issn1463-9076-
dc.identifier.urihttp://hdl.handle.net/1822/60303-
dc.description.abstractHerein, novel dehydropeptide-based magnetogels, based on the hydrogelators Npx-L-Phe-Z-ΔAbu-OH, Npx-L-Trp-Z-ΔPhe-OH and Npx-L-Ala-Z-ΔPhe-Gly-L-Arg-Gly-L-Asp-Gly-OH and containing manganese ferrite nanoparticles (diameters around 20 nm), were prepared and characterized. TEM and FTIR measurements showed that the magnetogels maintained the fibrous structure of neat hydrogels, with fibres of ca. 20 nm average width (generally in the range 10–30 nm) and a few conformational changes relative to the neat hydrogels. The magnetogels were tested as nanocarriers for two potential fluorescent antitumor drugs: a thienopyridine derivative and the natural compound curcumin. FRET (Förster resonance energy transfer) from the aromatic moieties (energy donors) of gels to the fluorescent drugs (energy acceptors) and fluorescence anisotropy measurements confirmed the incorporation of both drugs into the magnetogel matrices. The transport of both drugs loaded into the magnetogels to membrane models (small unilamellar vesicles) was assessed by FRET between the fluorescent drugs and the dye Nile Red. The magnetogel possessing the RGD sequence was most promising for the delivery of the thienopyridine derivative, whereas three magnetogels were found to be suitable for the delivery of curcumin.por
dc.description.sponsorshipUID/QUI/00686/2016; FCT Project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020); FCT Project PTDC/QUI-QOR/29015/2017 (POCI-01-0145-FEDER-029015)por
dc.language.isoengpor
dc.publisherRoyal Society of Chemistrypor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147414/PTpor
dc.rightsembargoedAccess (1 Year)por
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/por
dc.subjectPeptide-based hydrogelspor
dc.subjectMagnetic nanoparticlespor
dc.subjectDrug deliverypor
dc.subjectCurcuminpor
dc.subjectNew antitumor drugspor
dc.subjectCancer therapypor
dc.titleNovel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarrierspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlepdf/2019/cp/c9cp00352epor
oaire.citationStartPage10377por
oaire.citationEndPage10390por
oaire.citationIssue20por
oaire.citationVolume21por
dc.identifier.doi10.1039/C9CP00352Epor
rcaap.embargofctExigências da revista: período de embargo é de 12 meses.por
dc.date.embargo2020-04-23-
dc.identifier.pmid31065651por
dc.subject.fosEngenharia e Tecnologia::Nanotecnologiapor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
sdum.journalPhysical Chemistry Chemical Physicspor
Appears in Collections:PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)

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