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TitleSmall animal models
Author(s)da Silva Morais, Alain
Oliveira, J. M.
Reis, R. L.
Growth factors
Osteochondral regeneration strategies
Small animal models
Stem cells
Issue date2018
JournalAdvances in Experimental Medicine and Biology
Citationda Silva Morais A., Oliveira J. M., Reis R. L. Small Animal Models, Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances, Vol. 1059, pp. 423-439, doi:10.1007/978-3-319-76735-2_19, 2018
Abstract(s)Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic modalities prior to initiation of human clinical trials. Therefore, selecting a suitable experimental model for tissue engineering purposes is essential to establish valid conclusions. However, it remains important to be conscious of the advantages and limitations of the various small and large animal models frequently used for biomedical research as well as the different challenges encountered in extrapolating data obtained from animal studies and the risks of misinterpretation. This chapter discusses the various small animal model strategies used for osteochondral defect repair. Particular emphasis will be placed on analyzing the materials and strategies used in each model.
TypeBook part
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters

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