Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58781
Título: | Viral manipulation of the host metabolic network |
Autor(es): | Mesquita, Inês Morais Estaquier, Jérôme |
Palavras-chave: | Host cell metabolism Host–pathogen interaction Metabolic manipulation Viral infection |
Data: | 2018 |
Revista: | Experientia Supplementum |
Resumo(s): | Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successful infection. Viruses have evolved to retain a broad range of strategies to manipulate host cell metabolism and metabolic resources, channeling them toward the production of virion components leading to viral production. Although several viruses share similar strategies for manipulating host cell metabolism, these processes depend on several factors, namely, the viral life cycle and the metabolic and energetic status of the infected cell. Based on this knowledge, the development of new therapeutic approaches that circumvent viral spread through the target of altered metabolic pathways is an opportunity to tackle the infection. However, finding effective broad-spectrum strategies that aim at restoring to homeostasis the metabolic alterations induced upon virus infection is still a Holy Grail quest for antiviral therapies. Here, we review the strategies by which viruses manipulate host metabolism for their own benefit, with a particular emphasis on carbohydrate, glutamine, and lipid metabolism. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58781 |
DOI: | 10.1007/978-3-319-74932-7_10 |
ISSN: | 1664-431X |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Vira Manipulation of the Host Metabolic Network .pdf Acesso restrito! | 537,56 kB | Adobe PDF | Ver/Abrir |