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https://hdl.handle.net/1822/56859
Título: | Exploring glutathione as an adjuvant of anti-biofilm strategies against Pseudomonas aeruginosa |
Autor(es): | Monteiro, R. Pereira, Maria Olívia Sousa, Ana Margarida |
Data: | 2-Out-2018 |
Citação: | Monteiro, R.; Pereira, Maria Olívia; Sousa, Ana Margarida, Exploring glutathione as an adjuvant of anti-biofilm strategies against Pseudomonas aeruginosa. CHEMPOR 2018 - 13th International Chemical and Biological Engineering Conference (Book of Extended Abstracts). No. P-BB40, Aveiro, Portugal, Oct 2-4, 281-282, 2018. |
Resumo(s): | Pseudomonas aeruginosa biofilms are involved in several infectious diseases and their eradication remains a challenge. Disrupting the biofilm matrix is the most attractive way to facilitate biofilm-cells eradication and glutathione has been exhibiting great potential as a biofilm disrupter agent. Therefore, this study aimed to explore antibiofilm strategies based on the combination of glutathione with two in-use antibiotics. Biofilms were formed and subjected to the action of combinatorial arrangements of glutathione with ciprofloxacin or tobramycin. Preliminary results showed that PAO1 biofilms were eradicated using glutathione+ciprofloxacin, in contrast to biofilms formed by a clinical isolate (PAI). Better outcomes were obtained using glutathione+tobramycin since biomass reduction occurred with lower dosages. Also, a different action than the usually described for glutathione is suggested. In conclusion, glutathione-tobramycin could be a potential anti-biofilm strategy. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/56859 |
Versão da editora: | http://www.chempor2018.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49104_1.pdf | 181,09 kB | Adobe PDF | Ver/Abrir |