Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55608
Título: | Anti-virulent properties of a phage-encoded depolymerase against A. baumannii K2 capsular type |
Autor(es): | Oliveira, Hugo Costa, Ana Rita Ferreira, A. Mil-Homens, Dalila Fialho, Arsénio |
Data: | 9-Jul-2018 |
Citação: | Oliveira, Hugo; Costa, Ana Rita; Ferreira, A.; Mil-Homens, Dalila; Fialho, Arsénio, Anti-virulent properties of a phage-encoded depolymerase against A. baumannii K2 capsular type. Viruses of Microbes 2018 (EMBO Workshop) - Abstract Book. No. 225, Wroclaw, Poland, July 9-13, 324, 2018. |
Resumo(s): | [Excerpt] Capsular structures are seen as a universal virulence trait among gram-negative bacilli but sill poorly studied in Acinetobacter baumannii. Recent reports suggest that capsule structures are involved in evading or overwhelming microbial defenses and macromolecular antibiotics. The fact that at least 106 capsular types exist in A. baumannii may reflect the sophisticated and diverse protective mechanisms developed by this pathogen. In this study, we isolated a 93,641-bp phage infecting A. baumannii K2 capsular type and cloned its tail-associated depolymerase (B3gp42). The enzyme showed to digest extracted exopolysaccharides in a wide range of pH values (5 to 9), ionic strengths (0 to 500 mM) and temperatures (20 to 70°C). [...] |
Tipo: | Resumo em ata de conferência |
Descrição: | Viruses of Microbes 2018 (EMBO Workshop) - Abstract Book |
URI: | https://hdl.handle.net/1822/55608 |
Versão da editora: | http://meetings.embo.org/event/18-virus-microbe |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47851_1.pdf | 1,17 MB | Adobe PDF | Ver/Abrir | |
document_47851_2.pdf | 86,45 kB | Adobe PDF | Ver/Abrir |