Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/54614
Título: | Carvacrol is highly disruptive against coagulase-negative staphylococci in in vitro biofilms |
Autor(es): | Gaio, Vânia Silva Lima, Cláudia Sofia Afonso de Oliveira, Fernando Eduardo Freitas França, Ângela Maria Oliveira Sousa Cerca, Nuno |
Palavras-chave: | Antimicrobial resistance Biofilm Nosocomial infections |
Data: | 2017 |
Editora: | Future Medicine Ltd |
Revista: | Future Microbiology |
Citação: | Gaio, Vania; Lima, C.; Oliveira, Fernando E.; França, Angela; Cerca, Nuno, Carvacrol is highly disruptive against coagulase-negative staphylococci in in vitro biofilms. Future Microbiology, 12(16), 1487-1496, 2017 |
Resumo(s): | Aim: To evaluate the antimicrobial activity of carvacrol against stationary-phase planktonic and biofilm cells of coagulase-negative staphylococci and comparison to traditional antistaphylococcal antibiotics. MATERIALS & METHODS: The antimicrobial effect of carvacrol and antibiotics against planktonic and biofilm cells were assessed through quantification of the number of culturable and/or viable cells. Confocal laser scanning microscopy was used to evaluate the effect of carvacrol on the biofilm structure. RESULTS: A concentration of 4 mM of carvacrol demonstrated a potent antimicrobial effect, vastly superior than ciprofloxacin, rifampicin, gentamicin and vancomycin, both in planktonic and biofilm cells. CONCLUSION: Carvacrol is a potential antimicrobial agent, which applicability for the prevention and/or treatment of coagulase-negative staphylococci biofilm-associated infections is worthwhile investigating in more detail. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/54614 |
DOI: | 10.2217/fmb-2017-0122 |
ISSN: | 1746-0913 |
e-ISSN: | 1746-0921 |
Versão da editora: | http://www.futuremedicine.com/loi/fmb |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47353_1.pdf Acesso restrito! | 1,46 MB | Adobe PDF | Ver/Abrir |