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https://hdl.handle.net/1822/54029
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Bessa, P. C. | por |
dc.contributor.author | Pedro, A. J. | por |
dc.contributor.author | Nobre, Alexandra | por |
dc.contributor.author | Dungl, P. | por |
dc.contributor.author | Banerjee, A. | por |
dc.contributor.author | Dopler, D. | por |
dc.contributor.author | Klösch, B. | por |
dc.contributor.author | Redl, H. | por |
dc.contributor.author | Casal, M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2018-04-06T12:29:37Z | - |
dc.date.available | 2018-04-06T12:29:37Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | https://hdl.handle.net/1822/54029 | - |
dc.description.abstract | Bone tissue engineering has been an increasing field of research during the last years. The ideal approach for a regenerative application would consist in the use of cells from the patient, scaffolding materials and differentiation growth factors. Bone morphogenetic protein-2 (BMP-2) is one such growth factors with a strong ability to induce new bone and cartilage formation and has been used as a powerful osteoinductive component of several late-stage tissue engineering products for bone grafting. In this work, we aimed at obtaining high yields of human recombinant BMP-2 in a stable, pure and biologically active form by use of a new bacteria expression system that circumvents the disadvantages of conventional recombinant protein preparation methods and to perform a study of the stability conditions and the functionality of these peptides in vitro in human mesenchymal stem cells and C2C12 murine cell line. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (PhD Grant to PC Bessa, SFRH/BD/17049/2004). This work was also partially supported by the European STREP HIPPOCRATES (NMP3-CT-2003-505758) and carried out under the scope of European NoE EXPERTISSUES (NMP3-CT-2004- 500283). | por |
dc.language.iso | eng | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F17049%2F2004/PT | por |
dc.rights | openAccess | por |
dc.title | A novel system for producing human recombinant BMP-2 and study of the growth factor stabilizing conditions | por |
dc.type | conferencePoster | por |
dc.peerreviewed | yes | por |
oaire.citationConferenceDate | 11 Out. - 15 Out. 2006 | por |
sdum.event.title | 6th International Conference on Bone Morphogenetic Proteins | por |
sdum.event.type | congress | por |
oaire.citationConferencePlace | Cavtat, Croácia | por |
dc.subject.fos | Ciências Naturais::Ciências Biológicas | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Química | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia dos Materiais | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
Aparece nas coleções: | DBio - Comunicações/Communications in Congresses |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1180603042_Poster CROATIA.pdf | 975,03 kB | Adobe PDF | Ver/Abrir |