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https://hdl.handle.net/1822/52096
Título: | Altered functional connectivity of the default mode network in Williams syndrome: a multimodal approach |
Autor(es): | Sampaio, Adriana Moreira, Pedro Miguel Silva Osório, Ana Alexandra Caldas Magalhães, Ricardo José Silva Vasconcelos, Cristiana Fernandez, Montse Carracedo, Angel Alegria, Joana Gonçalves, Óscar F. Soares, José Miguel Montenegro |
Data: | 2016 |
Editora: | John Wiley & Sons |
Revista: | Developmental Science |
Resumo(s): | Resting state brain networks are implicated in a variety of relevant brain functions. Importantly, abnormal patterns of functional connectivity (FC) have been reported in several neurodevelopmental disorders. In particular, the Default Mode Network (DMN) has been found to be associated with social cognition. We hypothesize that the DMN may be altered in Williams syndrome (WS), a neurodevelopmental genetic disorder characterized by an unique cognitive and behavioral phenotype. In this study, we assessed the architecture of the DMN using fMRI in WS patients and typically developing matched controls (sex and age) in terms of FC and volumetry of the DMN. Moreover, we complemented the analysis with a functional connectome approach. After excluding participants due to movement artifacts (n=3), seven participants with WS and their respective matched controls were included in the analyses. A decreased FC between the DMN regions was observed in the WS group when compared with the typically developing group. Specifically, we found a decreased FC in a posterior hub of the DMN including the precuneus, calcarine and the posterior cingulate of the left hemisphere. The functional connectome approach showed a focalized and global increased FC connectome in the WS group. The reduced FC of the posterior hub of the DMN in the WS group is consistent with immaturity of the brain FC patterns and may be associated with the singularity of their visual spatial phenotype. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/52096 |
DOI: | 10.1111/desc.12443 |
ISSN: | 1363-755X |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CIPsi - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Altered functional connectivity of the default mode network in Williams syndrome- a multimodal approach.pdf Acesso restrito! | 397,1 kB | Adobe PDF | Ver/Abrir |