Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44899
Título: | Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages |
Autor(es): | Stucki, David Brites, Daniela Jeljeli, Leila Coscolla, Mireia Liu, Qingyun Trauner, Andrej Fenner, Lukas Rutaihwa, Liliana Borrell, Sonia Saraiva, Margarida |
Data: | 2016 |
Editora: | Nature Publishing Group |
Revista: | Nature Genetics |
Resumo(s): | Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44899 |
DOI: | 10.1038/ng.3704 |
ISSN: | 1061-4036 |
Versão da editora: | http://www.nature.com/ng/index.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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stucki2016.pdf | 5,51 MB | Adobe PDF | Ver/Abrir |