Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/43867
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Santos, Laurita dos | por |
dc.contributor.author | Téllez S, Claudio A. | por |
dc.contributor.author | Sousa, Mariane P. J. | por |
dc.contributor.author | Azóia, Nuno G. | por |
dc.contributor.author | Cavaco-Paulo, Artur | por |
dc.contributor.author | Martin, Airton A. | por |
dc.contributor.author | Favero, Priscila P. | por |
dc.date.accessioned | 2016-12-26T22:40:09Z | - |
dc.date.available | 2016-12-26T22:40:09Z | - |
dc.date.issued | 2017-03-05 | - |
dc.identifier.citation | Santos, Laurita dos; Téllez S, Claudio A.; Sousa, Mariane P. J.; Azoia, Nuno G.; Cavaco-Paulo, Artur; Martin, Airton A.; Favero, Priscila P., In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 174, 279-285, 2017 | por |
dc.identifier.issn | 1386-1425 | por |
dc.identifier.uri | https://hdl.handle.net/1822/43867 | - |
dc.description.abstract | Objective The purpose of this study is to elucidate the behavior of retinyl acetate in penetrating human skin without the presence of enhancers by using confocal Raman spectroscopy and molecular dynamics simulation. Methods In this study, in vivo confocal Raman spectroscopy was combined with molecular dynamics simulation to investigate the transdermal permeation of the aqueous suspension of retinyl acetate. Results Permeation was measured after 30 min, and retinyl acetate was found up to 20 m deep inside the stratum corneum. The delivery of retinyl acetate inside a skin membrane model was studied by molecular dynamics. The membrane model that was used represented normal young skin containing a lipid bilayer with 25% ceramide, 36% fatty acid, 30% cholesterol, and 6% cholesterol sulfate. Conclusion Spectroscopy data indicate that retinyl acetate permeates into the stratum corneum. Molecular dynamics data showed that retinyl acetate permeates in the membrane model and that their final location is deep inside the lipid bilayer. We showed, for the first time, a correlation between Raman permeation data and computational data. | por |
dc.description.sponsorship | C.A. Telléz S. would like to thank Capes/Brazil (88881.068140/2014-01 and 88887.125253/2015-00) for the grant. A.M. Cavaco-Paulo thanks Fapesp/Brazil (2014/05975-2) for the grant. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | In vivo confocal Raman spectroscopy | por |
dc.subject | Molecular dynamics | por |
dc.subject | Stratum corneum | por |
dc.subject | Retinyl acetate | por |
dc.subject | Skin penetration | por |
dc.title | In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.journals.elsevier.com/spectrochimica-acta-part-a-molecular-and-biomolecular-spectroscopy | por |
dc.comments | CEB46468 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 279 | por |
oaire.citationEndPage | 285 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationTitle | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | por |
oaire.citationVolume | 174 | por |
dc.date.updated | 2016-12-24T11:55:27Z | - |
dc.identifier.doi | 10.1016/j.saa.2016.11.042 | por |
dc.identifier.pmid | 27960141 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_46468_1.pdf | 2,55 MB | Adobe PDF | Ver/Abrir |