Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/28186
Título: | The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine |
Autor(es): | Martins, Ana M. Vunjak-Novakovic, Gordana Reis, R. L. |
Palavras-chave: | Cardiac differentiation Cardiac disease models Cardiac tissue engineering Induced pluripotent stem cells Patient-specific stem cells Pluripotency Regenerative medicine Reprogramming |
Data: | Jan-2014 |
Editora: | Springer |
Revista: | Stem Cell Reviews and Reports |
Citação: | Martins A. M., Vunjak-Novakovic G., Reis R. L. The Current Status of iPS Cells in Cardiac Research and Their Potential for Tissue Engineering and Regenerative Medicine, Stem Cell Reviews and Reports, doi:10.1007/s12015-013-9487-7, 2014 |
Resumo(s): | The recent availability of human cardiomyocytes derived from induced pluripotent stem (iPS) cells opens new opportunities to build in vitro models of cardiac disease, screening for new drugs, and patient-specific cardiac therapy. Notably, the use of iPS cells enables studies in the wide pool of genotypes and phenotypes. We describe progress in reprogramming of induced pluripotent stem (iPS) cells towards the cardiac lineage/differentiation. The focus is on challenges of cardiac disease modeling using iPS cells and their potential to produce safe, effective and affordable therapies/applications with the emphasis of cardiac tissue engineering. We also discuss implications of human iPS cells to biological research and some of the future needs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/28186 |
DOI: | 10.1007/s12015-013-9487-7 |
ISSN: | 1550-8943 |
Versão da editora: | http://download.springer.com/static/pdf/273/art%253A10.1007%252Fs12015-013-9487-7.pdf?auth66=1391958480_1baa901e13c8f36ca3e2b37135ad4a32&ext=.pdf |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17884-martins_ stem cell rev and rep.pdf Acesso restrito! | 401,1 kB | Adobe PDF | Ver/Abrir |