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TitleHuman mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
Author(s)Rodríguez-Valencia, Cosme
Pereiro, Iago
Pirraco, Rogério
Lopéz-Álvarez, M.
Serra, J.
González, P.
Marques, A. P.
Reis, R. L.
KeywordsCalcium phosphate
Human bone marrow-derived mesenchymal stem cells differentiation
Multi-doped coatings
Pulsed laser deposition
Issue date2014
JournalJournal of Biomaterials Applications
Abstract(s)The search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multidoping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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