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TitleCo-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)
Author(s)Oliveira, Antônio Talvane Torres
Pinheiro, Céline
Filho, A. L.
Brito, Maria José
Martinho, Olga
Matos, Delcio
Carvalho, André Lopes
Vazquez, Vinícius Lima
Silva, Thiago Buosi
Scapulatempo-Neto, Cristovam
Saad, Sarhan Sydney
Reis, R. M.
Baltazar, Fátima
KeywordsMonocarboxylate transporters
Cancer metabolism
Issue dateFeb-2012
PublisherSpringer Verlag
JournalJournal of Bioenergetics and Biomembranes
Abstract(s)Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher’s Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient’s overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.
DescriptionAntônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study
Prova tipográfica (uncorrected proof)
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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