Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/23854
Título: | Predictive biomarkers of bacillus calmette-guérin immunotherapy response in bladder cancer : where are we now? |
Autor(es): | Lima, Luís Ribeiro, Mário Dinis Longatto Filho, Adhemar Santos, Lúcio |
Data: | 2012 |
Editora: | Hindawi Publishing Corporation |
Revista: | Advances in Urology |
Resumo(s): | The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Gu´erin (the BCG vaccine). This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with highgrade tumours, T1 tumours, and in situ carcinomas. However, from 20% to 40% of the patients do not respond and frequently present tumour progression. Since BCG effectiveness is unpredictable, it is important to find consistent biomarkers that can aid either in the prediction of the outcome and/or side effects development. Accordingly, we conducted a systematic critical review to identify themost preeminent predictive molecular markers associated with BCG response. To the best of our knowledge, this is the first review exclusively focusing on predictive biomarkers for BCG treatment outcome. Using a specific query, 1324 abstracts were gathered, then inclusion/exclusion criteria were applied, and finally 87 manuscripts were included. Several molecules, including CD68 and genetic polymorphisms, have been identified as promising surrogate biomarkers. Combinatory analysis of the candidate predictive markers is a crucial step to create a predictive profile of treatment response |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/23854 |
DOI: | 10.1155/2012/232609 |
ISSN: | 1687-6369 |
Versão da editora: | http://www.hindawi.com/journals/au/2012/232609/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Lima Luis_Adv Urol. 2012.pdf | Documento principal | 560,29 kB | Adobe PDF | Ver/Abrir |