Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22113

TitleMolecular determinants of glioma risk and patient prognosis
Author(s)Costa, Bruno Marques
Magalhães, Ana Xavier
KeywordsBrain tumors
Gliomas
Neuro-Oncology
Biomarkers
HOXA9
EGFR
MGMT
EGF
Issue dateFeb-2012
PublisherLap Lambert Academic Publishing
Abstract(s)Gliomas encompass a wide variety of particularly devastating tumors, for which efficient therapies are not available. Their etiology remains mostly undetermined: so far, only exposure to high‐dose therapeutic radiation has been firmly established as a risk factor, but other plausible causes include genetic syndromes, familial aggregation, and genetic polymorphisms. The clinical performance status and patient age at diagnosis are definite features associated with outcome, but recent evidences suggest that tumor's molecular traits are also major determinants of prognosis. This book aims to review and discuss how molecular determinants may affect glioma risk and patient outcome, with a very special emphasis in glioblastoma multiforme, the most common and malignant glioma subtype. To do so, Part I presents a general introduction that summarizes the classification, epidemiology, and treatment of gliomas, while devoting particular attention to potential etiological factors and molecular alterations of these tumors. Part II presents original research studies emphasizing the relevance of particular biomarkers of glioma, particularly at the levels of glioma risk and patient prognosis.
Typebook
URIhttp://hdl.handle.net/1822/22113
ISBN978-3-8473-3502-3
Publisher versionhttps://www.morebooks.de/store/gb/book/molecular-determinants-of-glioma-risk-and-patient-prognosis/isbn/978-3-8473-3502-3
Peer-Reviewedyes
AccessrestrictedAccess
Appears in Collections:ICVS - Livros e Capítulos de Livros

Files in This Item:
File Description SizeFormat 
Costa B_Molecular Determinants Glial Tumors 2012.pdfDocumento principal4,47 MBAdobe PDFView/Open    Request a copy!

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis