Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22060
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Salgueiro, D. A. L. | - |
dc.contributor.author | Sousa, Cristina | - |
dc.contributor.author | Fortes, A. Gil | - |
dc.contributor.author | Alves, M. José | - |
dc.date.accessioned | 2012-12-21T18:33:22Z | - |
dc.date.available | 2012-12-21T18:33:22Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1389-5575 | por |
dc.identifier.uri | https://hdl.handle.net/1822/22060 | - |
dc.description.abstract | This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of derivatives. The study comprises glycosidase inhibition studies of the target compounds to a set of glycosidic enzymes, and evidenced molecular features that enhance or diminish their activity as glycosidase inhibitors. | por |
dc.language.iso | eng | por |
dc.publisher | Bentham Science Publishers | por |
dc.rights | openAccess | por |
dc.subject | Azafagomine | por |
dc.subject | Biological activity | por |
dc.subject | Diels-alder cycloaddition | por |
dc.subject | Glycosidase inhibitors | por |
dc.subject | Monocyclic analogs | por |
dc.subject | Azasugars | por |
dc.title | Diels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1465 | por |
oaire.citationEndPage | 1476 | por |
oaire.citationIssue | 14 | por |
oaire.citationTitle | Mini Reviews in Medicinal Chemistry | por |
oaire.citationVolume | 12 | por |
dc.identifier.doi | 10.2174/138955712803832663 | por |
dc.identifier.pmid | 22827178 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Mini Reviews in Medicinal Chemistry | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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MRMC-Manuscript-revised,2012,12,1465-1476.pdf | MRMC2012 | 1,2 MB | Adobe PDF | Ver/Abrir |