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TitleCasbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
Author(s)Carneiro, Victor Alves
Santos, Hélcio Silva dos
Arruda, Francisco Vassiliepe Sousa
Bandeira, Paulo Nogueira
Albuquerque, Maria Rose Jane Ribeiro
Pereira, Maria Olívia
Henriques, Mariana
Cavada, Benildo Sousa
Teixeira, Edson Holanda
KeywordsCasbane diterpene
Biofilm-associated infections control
Natural antimicrobials
Bacteria and yeast
Issue date4-Jul-2011
Abstract(s)Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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