Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14387
Título: | Injectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections |
Autor(es): | Balmayor, Elizabeth Rosado Baran, E. T. Azevedo, Helena S. Reis, R. L. |
Palavras-chave: | Starch-conjugated chitosan Gentamicin Microparticles Sustained release Staphylococcus aureus |
Data: | 2012 |
Editora: | Elsevier 1 |
Revista: | Carbohydrate Polymers |
Resumo(s): | Starch-conjugated chitosan microparticles were produced aimed to be used as a carrier for the long term sustained/controlled release of antibiotic drugs to control bone infection. The microparticles were prepared by a reductive alkylation crosslinking method. The obtained microparticles showed a spherical shape, with a slightly rough and porous surface, and a size range of 80–150 μm. Gentamicin was entrapped into the starch-conjugated chitosan microparticles and its release profile was studied in vitro. Increasing concentrations of gentamicin (from 50 to 150 mg/mL) led to a decrease in the encapsulation efficiency (from 67 to 55%), while drug loading increased from 4 to 27%. A sustained release of gentamicin was observed over a period of 30 days. The release kinetics could be controlled using an ionic crosslinker agent. In addition, a bacterial inhibition test on Staphylococcus aureus shows a diameter of the sample inhibition zone ranging from 12 to 17 mm (70–100% of relative activity). |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14387 |
DOI: | 10.1016/j.carbpol.2011.06.078 |
ISSN: | 0144-8617 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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InjectableStarchChitosanMicroparticles_Gentamicin_ERBalmayor_CarbohydratePolym2012.pdf Acesso restrito! | Main artilcle | 879,55 kB | Adobe PDF | Ver/Abrir |