Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging

doi:10.1016/j.bmcl.2010.10.059

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/14303

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Campo DC	Valor	Idioma
dc.contributor.author	Sá, Arsénio Vasconcelos	-
dc.contributor.author	Matias, Áurea A.	-
dc.contributor.author	Prata, M. Isabel M.	-
dc.contributor.author	Geraldes, Carlos F. G. C.	-
dc.contributor.author	Ferreira, Paula M. T.	-
dc.contributor.author	André, João P.	-
dc.date.accessioned	2011-11-14T15:47:02Z	-
dc.date.available	2011-11-14T15:47:02Z	-
dc.date.issued	2010	-
dc.identifier.issn	0960-894X	por
dc.identifier.uri	https://hdl.handle.net/1822/14303	-
dc.description.abstract	We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.	por
dc.description.sponsorship	Fundação para a Ciência e a Tecnologia (FCT)	por
dc.language.iso	eng	por
dc.publisher	Elsevier	por
dc.relation	info:eu-repo/grantAgreement/FCT/5876-PPCDTI/70063/PT	-
dc.rights	openAccess	por
dc.subject	Triaza	por
dc.subject	Orthogonal protection	por
dc.subject	Bifunctional chelators	por
dc.subject	Gallium	por
dc.subject	Radiopharmacy	por
dc.subject	Integrin αѵβ₃receptor	por
dc.subject	Integrin alpha(v)beta(3) receptor	por
dc.subject	Integrin a ß receptor ? 3	por
dc.subject	Integrin α β receptor ν 3	por
dc.title	Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging	por
dc.type	article	por
dc.peerreviewed	yes	por
sdum.publicationstatus	published	por
oaire.citationStartPage	7345	por
oaire.citationEndPage	7348	por
oaire.citationIssue	24	por
oaire.citationTitle	Bioorganic and Medicinal Chemistry Letters	por
oaire.citationVolume	20	por
dc.identifier.doi	10.1016/j.bmcl.2010.10.059	por
dc.identifier.pmid	21106453	por
dc.subject.wos	Science & Technology	por
sdum.journal	Bioorganic and Medicinal Chemistry Letters	por
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