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TitleGallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
Author(s)Sá, Arsénio Vasconcelos
Matias, Áurea A.
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
Ferreira, Paula M. T.
André, João P.
Orthogonal protection
Bifunctional chelators
Integrin αѵβ₃receptor
Integrin alpha(v)beta(3) receptor
Integrin a ß receptor ? 3
Integrin α β receptor ν 3
Issue date2010
JournalBioorganic and Medicinal Chemistry Letters
Abstract(s)We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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