Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/14303

TitleGallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
Author(s)Sá, Arsénio Vasconcelos
Matias, Áurea A.
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
Ferreira, Paula M. T.
André, João P.
KeywordsTriaza
Orthogonal protection
Bifunctional chelators
Gallium
Radiopharmacy
Integrin αѵβ₃receptor
Integrin alpha(v)beta(3) receptor
Integrin a ß receptor ? 3
Integrin α β receptor ν 3
Issue date2010
PublisherElsevier
JournalBioorganic and Medicinal Chemistry Letters
Abstract(s)We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.
TypeArticle
URIhttp://hdl.handle.net/1822/14303
DOI10.1016/j.bmcl.2010.10.059
ISSN0960-894X
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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