Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/14267

TitleGa(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies
Author(s)Fontes, André Filipe Gomes Soares
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
André, João P.
KeywordsDOTA
Gallium
Amphiphilic
Micelles
Radiopharmacy
PET
Issue date2011
PublisherElsevier
JournalNuclear Medicine and Biology
Abstract(s)In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micelle concentration), their stability in blood serum and their lipophilicity (logP) were investigated. Biodistribution studies with the 67Ga-labeled chelates were performed in Wistar rats showing a predominant liver uptake with almost no traces of the radiochelates in the body after 24 hours.
TypeArticle
URIhttp://hdl.handle.net/1822/14267
DOI10.1016/j.nucmedbio.2010.10.003
ISSN0969-8051
Publisher versionhttp://www.elsevier.com/wps/find/journaldescription.cws_home/525482/description
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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