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TitleMineralization of chitosan membrane using a double diffusion system for bone related applications
Author(s)Gomes, Sílvia C.
Boulon, M. E.
Oliveira, A. L.
Leonor, I. B.
Mano, J. F.
Reis, R. L.
KeywordsChitosan membranes
Calcium-phosphate coating
Double diffusion system
Issue date2008
PublisherTrans Tech Publications
JournalMaterials Science Forum
Abstract(s)Chitosan membranes were subjected to a pre-treatment in a double diffusion system, with a calcium solution in one chamber and a phosphate solution in the other chamber. Both chambers were separated by the chitosan membrane and subject to three mineralization periods (5, 10 and 15 minutes). After this pre-treatment the bioactivity of the different calcium phosphate coatings formed was tested for different periods of immersion time, 7, 14 and 21 days at room temperature and 37ºC, in acellular simulated body fluid (1.0x). The results obtained demonstrated that the calcium phosphate coatings formed during the pre-treatment process are bioactive. It was found that the calcification is effective just in the side of the membrane exposed to the calcium solution chamber. This enabled to develop membranes with asymmetric osteoinductive properties that can be useful in different orthopedic applications.
TypeConference paper
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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