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Issue DateTitleAuthor(s)TypeAccess
2007Análise da exposição tabágica no domicílio e suas repercussões respiratórias em crianças do ensino básico da cidade de BragaBulhões, Cláudia; Silva, Cristina Nogueira; Ferreira, Daniela, et al.ArticleOpen access
1-Jul-2016Atrésia Esofágica: Um Desafio desde o Diagnóstico Pré-natal ao Tratamento CirúrgicoTrocado, Vera; Barroso, Catarina; Silva, Cristina Isabel Nogueira, et al.ArticleOpen access
2007Avaliação da taxa de cobertura vacinal no Centro de Saúde de Braga, nas coortes de nascimento de 1990 a 2005Silva, Cristina Nogueira; Gonçalves, Jean PierreArticleOpen access
Sep-2006Background Previous morphological studies had produced controversial results with regard to heart development in congenital diaphragmatic hernia (CDH), whereas a few publications investigated cardiac function and myocardial maturation. Myocardium maturation is associated with age-dependent increasing of gene expression of gap junction protein connexin 43 (Cx43), adenosine triphosphatase of the sarcoplasmic reticulum (SERCA2a), as well as switching of myosin heavy chains (MHCs) from β to α isoforms. Our aim was to evaluate myocardium maturity in nitrofen-induced CDH rat model. Methods Fetuses from dated pregnant Sprague-Dawley rats were assigned to 3 experimental groups: control, nitrofen (exposed to nitrofen, without CDH), and CDH (exposed to nitrofen, with CDH). Myocardial samples collected from left ventricle free wall were processed to (i) quantification of messenger RNA (mRNA) of Cx43, SERCA2a, α and β MHC isoforms, as well as β-actin (housekeeping gene); and (ii) separation of MHC isoforms (α and β isoforms) by sodium dodecyl sulfate polyacrylamide gel electrophoresis silver stained. Results We demonstrated that there is no difference in myocardial gene expression of Cx43 (control, 1.0 ± 0.1; nitrofen, 1.1 ± 0.2; CDH, 1.3 ± 0.2) and SERCA2a (control, 1.0 ± 0.1; nitrofen, 0.9 ± 0.1; CDH, 1.0 ± 0.2). Myocardial gene expressions of α and β mRNA of MHC isoforms were slightly decreased both in nitrofen and CDH fetuses when compared with control fetuses, but evaluation of the α-to-β ratios of MHC isoforms at protein level revealed no significant differences between CDH and control (control, 16.9 ± 2.5; CDH, 17.0 ± 2.0). Conclusions Myocardial quantification of Cx43 and SERCA2a mRNA, as well as the expression pattern of MHC isoforms at protein levels, was similar in all studied groups. We predict, therefore, that acute heart failure commonly observed in CDH infants might be attributed predominantly to cardiac overload secondary to severe pulmonary hypertension rather than to myocardial immaturity.Baptista, Maria João; Recamán, Mónica; Rocha, Gustavo Filipe Melo Alves, et al.ArticleRestricted access (UMinho)
2013Bladder endometriosis: a diagnostic challengeSilva, Cristina Isabel Nogueira; Leitão, T. P.; Osório, F.ArticleRestricted access (Author)
2015Clear cell adenocarcinoma of the cervix in a young woman: a diagnostic challengeSilva, Cristina Nogueira; Silva, Ana Isabel; Rocha, Afonso, et al.ArticleOpen access
2014Contraceção e risco de tromboembolismo venoso : um estudo caso-controloGuimarães, Ana Catarina; Costa, Patrício Soares; Rocha, Afonso, et al.ArticleOpen access
2020Decellularized human chorion membrane as a novel biomaterial for tissue regenerationFrazão, Laura Passos Morgado Franco; Castro, Joana Vieira de; Silva, Cristina Isabel Nogueira, et al.ArticleOpen access
2015Diabetes gestacional: determinação de fatores de risco para diabetes mellitusRibeiro, Ana Maria Carvalho; Silva, Cristina Nogueira; Rocha, Gustavo Melo, et al.ArticleOpen access
Sep-2007Embryonic essential myosin light chain regulates fetal lung development in ratsSantos, Marta; Moura, Rute S.; Gonzaga, Sílvia, et al.ArticleRestricted access (UMinho)
12-Jan-2014Episiotomy: early maternal and neonatal outcomes of selective versus routine useSilva, Cristina Nogueira; Coutada, Rosália Silva; Rocha, AfonsoArticleOpen access
Dec-2008Ghrelin and obestatin: different role in fetal lung development?Nunes, Susana Maria Fialho; Silva, Cristina Isabel Nogueira; Dias, Emanuel Carvalho, et al.ArticleRestricted access (UMinho)
Apr-2006Ghrelin expression in human and rat fetal lungs and the effect of ghrelin administration in nitrofen-induced congenital diaphragmatic herniaSantos, Marta; Bastos, Pedro; Gonzaga, Silvia, et al.ArticleOpen access
2014Histerectomia totalmente laparoscópica: análise retrospetiva de 262 casosSilva, Cristina Nogueira; Ribeiro, Samuel Santos; Barata, Sónia, et al.ArticleOpen access
Nov-2006IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branchingSilva, Cristina Isabel Nogueira; Santos, Marta; Baptista, Maria J., et al.ArticleOpen access
2013Improving fECG signal acquisition in the evaluation of fetal well-beingGonçalves, C.; Sousa, Joana; Silva, Cristina Nogueira, et al.Conference paperRestricted access (UMinho)
Jul-2008Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6Silva, Cristina Isabel Nogueira; Moura, Rute S.; Esteves, Nuno, et al.ArticleRestricted access (UMinho)
Jan-2012Leukemia inhibitory factor in rat fetal lung development : expression and functional studiesSilva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho, et al.ArticleOpen access
Mar-2012Local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic herniaSilva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C., et al.ArticleOpen access
19-Jun-2012Looking for novel physiological regulators of lung developmentSilva, Cristina Isabel NogueiraDoctoral thesisOpen access